Nitric Oxide Synthase 3-Mediated Neurodegeneration After Intracerebral Gene Delivery
نویسندگان
چکیده
منابع مشابه
Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery.
In Alzheimer disease (AD), increased nitric oxide synthase 3 (NOS3) expression correlates with apoptosis in cortical neurons and colocalizes with amyloid precursor protein (APP)-amyloid beta (Abeta) deposits in the brain. In the present study we examined the potential role of NOS3 in relation to AD-type neurodegeneration using an in vivo model of gene delivery. Long Evans rat pups were given a ...
متن کاملNitric-oxide synthase and neurodegeneration/neuroprotection.
Glaucoma is an optic neuropathy in which the retinal ganglion cells and their axons, which package and transmit visual impulses from the photoreceptors and associated retinal interneurons to the brain, die individually or in small groups, typically over many years (Figs. 1 and 2) (1). The resulting functional deficit is the second leading cause of irreversible visual loss in the U.S., and the m...
متن کاملThe Study of Nitric Oxide Synthase 3 (NOS3) T-786C and 4a4b Gene Polymorphism in Iranian Men with Varicocele
Background and Objectives: Varicocele is one of the most common causes of male infertility. Varicocele is an abnormal dilatation and tortuosity of veins of the pampiniform plexus, which drain the testis. Studies have shown that elevated level of oxidative stress markers, such as nitric oxide (NO) in the dilated veins of patients with varicocele impair testicular function. The aim of this study,...
متن کاملP-131: The Study of Nitric Oxide Synthase 3 (NOS3) 4a4b Gene Polymorphism in Iranian Infertile Men with Varicocele
Background Varicocele is an abnormal dilation and tortuosity of veins of pampiniform plexus that drains the testis and causes an important change in semen.This abnormality is often one of the most common risk factors for male infertility. The aim of this study was to investigate the relationship between nitric oxide synthase 3 (NOS3) 4a4b (rs61722009) gene polymorphism, as a common genetic fact...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2007
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e318040cfa2